Arun Bokde investigates how large-scale brain networks function and how they are associated with both normal cognition, such as memory and attention, and breakdowns that lead to brain disorders. He brings neuroscientific expertise to the GBHI trainees to help build their scientific foundation and sharpen their analytical analysis of brain health science.
Bokde uses functional magnetic resonance imaging to measure brain activation during visual perceptual tasks, as well as working memory tasks in persons with mild cognitive impairment, patients with Alzheimer’s disease (AD), and healthy participants. These studies provide an understanding of how disease affects not only memory networks, but also perceptual processes in the brain. Recent findings were the basis of a new approach to testing AD–related drugs. In addition, Bokde has investigated the structural integrity of brain networks using diffusion imaging in combination with tractography in the limbic system, a network associated with memory function and profoundly affected in patients with AD. Bokde has also led an international project to develop training resources for the application of neuroimaging to the diagnostic process of AD patients, as well as developing resources for patients and their families to gain a better understanding of the disease.
In conjunction with GBHI, Bokde is member of two large European neuroimaging consortia investigating AD: the European DTI Study on Dementia and IMAGEN, a study of high-risk behaviors and mental disorders.
Bio: Arun Bokde is an assistant professor of neuroimaging in the Department of Psychiatry, School of Medicine at Trinity College Dublin. He leads the Cognitive Systems Group and is a principal investigator in the Trinity College Institute of Neuroscience. He was a postdoctoral research fellow at the National Institute on Aging and at the National Institute of Mental Health, and later was a research scientist at Ludwig Maximilian University in Munich, Germany. He obtained his PhD degree at the University of Texas at Austin.