Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective

Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimers Dement. 2022 Apr 8. doi: 10.1002/alz.12662. Online ahead of print.


Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable risk factors for intervention. However, few epidemiological or clinical ADRD studies examine sex differences; even fewer evaluate gender in the context of ADRD risk. The goals of this perspective are to: (1) provide definitions of gender, biologic sex, and sexual orientation. and the limitations of examining these as binary variables; (2) provide an overview of what is known with regard to sex and gender differences in the risk, prevention, and diagnosis of ADRD; and (3) discuss these sex and gender differences from a global, worldwide perspective. Identifying drivers of sex and gender differences in ADRD throughout the world is a first step in developing interventions unique to each geographical and sociocultural area to reduce these inequities and to ultimately reduce global ADRD risk. HIGHLIGHTS: The burden of dementia is unevenly distributed geographically and by sex and gender. Scientific advances in genetics and biomarkers challenge beliefs that sex is binary. Discrimination against women and sex and gender minority (SGM) populations contributes to cognitive decline. Sociocultural factors lead to gender inequities in Alzheimer's disease and related dementias (ADRD) worldwide.

PMID:35394117 | DOI:10.1002/alz.12662


Michelle M Mielke
Neelum T Aggarwal
Clara Vila-Castelar
Puja Agarwal
Eider M Arenaza-Urquijo
Benjamin Brett
Anna Brugulat-Serrat
Lyndsey E DuBose
Willem S Eikelboom
Jason Flatt
Nancy S Foldi
Sanne Franzen
Paola Gilsanz
Wei Li
Alison J McManus
Debora Melo van Lent
Sadaf Arefi Milani
C Elizabeth Shaaban
Shana D Stites
Erin Sundermann
Vidyani Suryadevara
Jean-Francoise Trani
Arlener D Turner
Jet M J Vonk
Yakeel T Quiroz
Ganesh M Babulal
Diversity and Disparity Professional Interest Area Sex and Gender Special Interest Group