Alzheimers Dement (Amst). 2023 Jul 8;15(3):e12455. doi: 10.1002/dad2.12455. eCollection 2023 Jul-Sep.
ABSTRACT
INTRODUCTION: Harmonization protocols that address batch effects and cross-site methodological differences in multi-center studies are critical for strengthening electroencephalography (EEG) signatures of functional connectivity (FC) as potential dementia biomarkers.
METHODS: We implemented an automatic processing pipeline incorporating electrode layout integrations, patient-control normalizations, and multi-metric EEG source space connectomics analyses.
RESULTS: Spline interpolations of EEG signals onto a head mesh model with 6067 virtual electrodes resulted in an effective method for integrating electrode layouts. Z-score transformations of EEG time series resulted in source space connectivity matrices with high bilateral symmetry, reinforced long-range connections, and diminished short-range functional interactions. A composite FC metric allowed for accurate multicentric classifications of Alzheimer's disease and behavioral variant frontotemporal dementia.
DISCUSSION: Harmonized multi-metric analysis of EEG source space connectivity can address data heterogeneities in multi-centric studies, representing a powerful tool for accurately characterizing dementia.
PMID:37424962 | PMC:PMC10329259 | DOI:10.1002/dad2.12455
Authors
Agustín Ibáñez, PhD
Neuroscientist
