NPJ Dement. 2025;1(1):18. doi: 10.1038/s44400-025-00015-1. Epub 2025 Jul 30.
ABSTRACT
The Asian Cohort for Alzheimer's Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset's efficacy. Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen's Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen's Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.
PMID:40757175 | PMC:PMC12310511 | DOI:10.1038/s44400-025-00015-1
Authors
Boon Lead Tee, MD, MS
Neurologist
