Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults

Scientific reports

Sci Rep. 2022 Oct 13;12(1):17197. doi: 10.1038/s41598-022-20627-4.

ABSTRACT

Blood pressure variability is an emerging risk factor for Alzheimer's disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer's disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer's disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55-88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1-42 (standardized ß = - 0.36 [95% CI - 0.61, - 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1-42: Aβ1-40 ratio (ß = - 0.49 [95% CI - 0.71, - 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1-42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer's disease pathophysiology.

PMID:36229634 | PMC:PMC9561652 | DOI:10.1038/s41598-022-20627-4

Authors

Isabel J Sible
Belinda Yew
Jung Yun Jang
John Paul M Alitin
Yanrong Li
Aimée Gaubert
Amy Nguyen
Shubir Dutt
Anna E Blanken
Jean K Ho
Anisa J Marshall
Arunima Kapoor
Fatemah Shenasa
Kathleen E Rodgers
Virginia E Sturm
Elizabeth Head
Alessandra Martini
Daniel A Nation