Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets

Annual review of pharmacology and toxicology

Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:321-340. doi: 10.1146/annurev-pharmtox-051921-112525. Epub 2022 Sep 13.


With the worldwide increase in life span, surgical patients are becoming older and have a greater propensity for postoperative cognitive impairment, either new onset or through deterioration of an existing condition; in both conditions, knowledge of the patient's preoperative cognitive function and postoperative cognitive trajectory is imperative. We describe the clinical utility of a tablet-based technique for rapid assessment of the memory and attentiveness domains required for executive function. The pathogenic mechanisms for perioperative neurocognitive disorders have been investigated in animal models in which excessive and/or prolonged postoperative neuroinflammation has emerged as a likely contender. The cellular and molecular species involved in postoperative neuroinflammation are the putative targets for future therapeutic interventions that are efficacious and do not interfere with the surgical patient's healing process.

PMID:36100220 | DOI:10.1146/annurev-pharmtox-051921-112525