Baseline MRI atrophy predicts 2-year cognitive outcomes in early-onset Alzheimer's disease

Journal of neurology

J Neurol. 2021 Oct 19. doi: 10.1007/s00415-021-10851-9. Online ahead of print.


BACKGROUND: MRI atrophy predicts cognitive status in AD. However, this relationship has not been investigated in early-onset AD (EOAD, < 65 years) patients with a biomarker-based diagnosis.

METHODS: Forty eight EOAD (MMSE ≥ 15; A + T + N +) and forty two age-matched healthy controls (HC; A - T - N -) from a prospective cohort underwent full neuropsychological assessment, 3T-MRI scan and lumbar puncture at baseline. Participants repeated the cognitive assessment annually. We used linear mixed models to investigate whether baseline cortical thickness (CTh) or subcortical volume predicts two-year cognitive outcomes in the EOAD group.

RESULTS: In EOAD, hemispheric CTh and ventricular volume at baseline were associated with global cognition, language and attentional/executive functioning 2 years later (p < 0.0028). Regional CTh was related to most cognitive outcomes (p < 0.0028), except verbal/visual memory subtests. Amygdalar volume was associated with letter fluency test (p < 0.0028). Hippocampal volume did not show significant associations.

CONCLUSION: Baseline hemispheric/regional CTh, ventricular and amygdalar volume, but not the hippocampus, predict two-year cognitive outcomes in EOAD.

PMID:34665329 | DOI:10.1007/s00415-021-10851-9


José Contador
Agnès Pérez-Millan
Nuria Guillen
Adrià Tort-Merino
Mircea Balasa
Neus Falgàs
Jaume Olives
Magdalena Castellví
Sergi Borrego-Écija
Beatriz Bosch
Guadalupe Fernández-Villullas
Oscar Ramos-Campoy
Anna Antonell
Nuria Bargalló
Raquel Sanchez-Valle
Roser Sala-Llonch
Albert Lladó