The moderation effect of cognitive reserve on the longitudinal association between depression and cognitive performance among older adults

Aging Ment Health. 2025 Aug 14:1-10. doi: 10.1080/13607863.2025.2545360. Online ahead of print.

ABSTRACT

OBJECTIVES: This study examines the relationship between depression and cognitive performance in older adults and explores how cognitive reserve (CR) - measured through a composite score of education, occupational complexity, and cognitive activities, as well as each individual component - moderates this relationship over a 4-year period.

METHOD: Data from 32,325 participants aged 50+ in the Survey of Health, Aging, and Retirement in Europe (SHARE) were analyzed. Cognitive performance was measured using memory, numeracy, and verbal fluency tests at baseline and after four years. Depressive symptoms were assessed with the EURO-D scale, and CR was evaluated through education, occupational complexity, and cognitive activity engagement. Moderation analyses were conducted using a bias-corrected bootstrap approach with 5,000 resamples.

RESULTS: Lower and average CR levels were linked to a stronger negative association between depression and cognitive performance, while higher CR showed no adverse effects. Education and cognitive activities significantly reduced the impact on cognitive function, whereas occupational complexity had no significant effect.

CONCLUSION: Cognitive reserve, particularly through education and cognitive activities, moderates the impact of depression on cognitive performance in older adults. Public health strategies should promote CR-enhancing activities to protect cognitive health in later life.

PMID:40808606 | DOI:10.1080/13607863.2025.2545360