Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS)
Alzheimers Dement. 2023 Sep 10. doi: 10.1002/alz.13453. Online ahead of print.
ABSTRACT
INTRODUCTION: We aimed to describe baseline amyloid-beta (Aβ) and tau-positron emission tomograrphy (PET) from Longitudinal Early-onset Alzheimer's Disease Study (LEADS), a prospective multi-site observational study of sporadic early-onset Alzheimer's disease (EOAD).
METHODS: We analyzed baseline [18F]Florbetaben (Aβ) and [18F]Flortaucipir (tau)-PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years. Florbetaben scans were used to distinguish cognitively impaired participants with EOAD (Aβ+) from EOnonAD (Aβ-) based on the combination of visual read by expert reader and image quantification.
RESULTS: 243/321 (75.7%) of participants were assigned to the EOAD group based on amyloid-PET; 231 (95.1%) of them were tau-PET positive (A+T+). Tau-PET signal was elevated across cortical regions with a parietal-predominant pattern, and higher burden was observed in younger and female EOAD participants.
DISCUSSION: LEADS data emphasizes the importance of biomarkers to enhance diagnostic accuracy in EOAD. The advanced tau-PET binding at baseline might have implications for therapeutic strategies in patients with EOAD.
HIGHLIGHTS: 72% of patients with clinical EOAD were positive on both amyloid- and tau-PET. Amyloid-positive patients with EOAD had high tau-PET signal across cortical regions. In EOAD, tau-PET mediated the relationship between amyloid-PET and MMSE. Among EOAD patients, younger onset and female sex were associated with higher tau-PET.
PMID:37690109 | DOI:10.1002/alz.13453
Authors
![Hanna Cho headshot](/sites/default/files/styles/image_1x1_small/public/profile/HC_picture.jpg?h=d12cc296&itok=xPrnDPEW)
Hanna Cho, MD, PhD
Neurologist
![Charles Windon headshot](/sites/default/files/styles/image_1x1_small/public/profile/CharlesWindon_orig.jpg?h=ef2e206c&itok=SfWg-ECk)
Charles Windon, MD
Assistant Professor of Clinical Neurology
![Lea Grinberg headshot 2021](/sites/default/files/styles/image_1x1_small/public/profile/Grinberg_Lea%20%281%29.jpg?h=a09a6676&itok=ispOx_-8)
Lea Tenenholz Grinberg, MD, PhD
Professor of Neurology and Pathology
![Joel Kramer](/sites/default/files/styles/image_1x1_small/public/profile/Joel_Kramer.jpg?h=17c4d544&itok=WDjIGUzD)
Joel Kramer, PsyD
Professor of Neuropsychology