Associations of delay discounting and drinking trajectories from ages 14 to 22

Alcoholism, clinical and experimental research

Alcohol Clin Exp Res. 2022 Apr;46(4):667-681. doi: 10.1111/acer.14799. Epub 2022 Mar 17.

ABSTRACT

BACKGROUND: While drinking alcohol, one must choose between the immediate rewarding effects and the delayed reward of a healthier lifestyle. Individuals differ in their devaluation of a delayed reward based on the time required to receive it, i.e., delay discounting (DD). Previous studies have shown that adolescents discount more steeply than adults and that steeper DD is associated with heavier alcohol use in both groups.

METHODS: In a large-scale longitudinal study, we investigated whether higher rates of DD are an antecedent or a consequence of alcohol use during adolescent development. As part of the IMAGEN project, 2220 adolescents completed the Monetary Choice Questionnaire as a DD measure, the Alcohol Use Disorders Identification Test, and the Timeline Follow Back interview at ages 14, 16, 18, and 22. Bivariate latent growth curve models were applied to investigate the relationship between DD and drinking. To explore the consequences of drinking, we computed the cumulative alcohol consumption and correlated it with the development of discounting. A subsample of 221 participants completed an intertemporal choice task (iTeCh) during functional magnetic resonance imaging at ages 14, 16, and 18. Repeated-measures ANOVA was used to differentiate between high-risk and low-risk drinkers on the development of neural processing during intertemporal choices.

RESULTS: Overall, high rates of DD at age 14 predicted a greater increase in drinking over 8 years. In contrast, on average, moderate alcohol use did not affect DD from ages 14 to 22. Of note, we found indicators for less brain activity in top-down control areas during intertemporal choices in the participants who drank more.

CONCLUSIONS: Steep DD was shown to be a predictor rather than a consequence of alcohol use in low-level drinking adolescents. Important considerations for future longitudinal studies are the sampling strategies to be used and the reliability of the assessments.

PMID:35257381 | PMC:PMC9018624 | DOI:10.1111/acer.14799

Authors

Juliane H Fröhner
Stephan Ripke
Sarah Jurk
Shu-Chen Li
Tobias Banaschewski
Arun L W Bokde
Erin Burke Quinlan
Sylvane Desrivières
Herta Flor
Antoine Grigis
Hugh Garavan
Andreas Heinz
Rüdiger Brühl
Jean-Luc Martinot
Marie-Laure Paillère Martinot
Eric Artiges
Frauke Nees
Dimitri Papadopoulos Orfanos
Luise Poustka
Sarah Hohmann
Henrik Walter
Robert Whelan
Gunter Schumann
Michael N Smolka
IMAGEN Consortium