A common outcome set for trials in dementia with Lewy bodies (DLB COS)

Alzheimers Dement (N Y). 2025 Jul 11;11(3):e70134. doi: 10.1002/trc2.70134. eCollection 2025 Jul-Sep.

ABSTRACT

INTRODUCTION: Methodological heterogeneity in dementia with Lewy bodies (DLB) trials contributes to publication bias and makes evidence synthesis and meta-analysis challenging. We aimed to develop a core outcome set for DLB (DLB COS) trials to improve consistency and comparability in DLB research.

METHODS: We conducted a systematic review to identify outcomes and administered a two-stage Delphi survey to a diverse panel of lay and professional stakeholders. We asked respondents which outcomes should be prioritized and included in DLB COS.

RESULTS: Forty-nine outcomes were presented to survey respondents. Consensus was reached regarding eight outcomes for the final DLB COS: delusions/paranoia; fluctuations in cognition, attention, and arousal; functioning; global cognition; hallucinations; quality of life; motor parkinsonism; and rapid eye movement sleep behavior disorder.

DISCUSSION: If adopted, DLB COS can enhance the comparability of research findings and facilitate standardization and harmonization.

HIGHLIGHTS: A systematic review revealed heterogeneity in dementia with Lewy bodies (DLB) study outcomes.Our study produced a DLB Core Outcome Set (DLB COS) comprising eight outcomes.DLB COS sets the minimum reporting standards for future trials.DLB-specific rating scales incorporating these outcomes are needed.Addressing this gap is a strategic priority in DLB research.

PMID:40657378 | PMC:PMC12254044 | DOI:10.1002/trc2.70134