Biomarkers for dementia in Latin American countries: Gaps and opportunities

Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimers Dement. 2022 Sep 13. doi: 10.1002/alz.12757. Online ahead of print.

ABSTRACT

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

PMID:36098676 | DOI:10.1002/alz.12757

Authors

Mario A Parra
Paulina Orellana
Tomas Leon
Cabello G Victoria
Fernando Henriquez
Rodrigo Gomez
Constanza Avalos
Andres Damian
Andrea Slachevsky
Agustin Ibañez
Henrik Zetterberg
Betty M Tijms
Jennifer S Yokoyama
Stefanie D Piña-Escudero
J Nicholas Cochran
Diana L Matallana
Daisy Acosta
Ricardo Allegri
Bianca P Arias-Suárez
Bernardo Barra
Maria Isabel Behrens
Sonia M D Brucki
Geraldo Busatto
Paulo Caramelli
Sheila Castro-Suarez
Valeria Contreras
Nilton Custodio
Sergio Dansilio
Myriam De la Cruz-Puebla
Leonardo Cruz de Souza
Monica M Diaz
Lissette Duque
Gonzalo A Farías
Sergio T Ferreira
Nahuel Magrath Guimet
Ana Kmaid
David Lira
Francisco Lopera
Beatriz Mar Meza
Eliane C Miotto
Ricardo Nitrini
Alberto Nuñez
Santiago O'Neill
John Ochoa
Maritza Pintado-Caipa
Elisa de Paula França Resende
Shannon Risacher
Luz Angela Rojas
Valentina Sabaj
Lucas Schilling
Allis F Sellek
Ana Sosa
Leonel T Takada
Antonio L Teixeira
Martha Unaucho-Pilalumbo
Claudia Duran-Aniotz