This project fosters a consortium of multiple partners aimed to expand dementia research in Latin America and the Caribbean (LAC). The consortium aims to combine genomic, neuroimaging and behavioral data to improve dementia characterization in diverse populations. This 5-year project constitutes an excellent opportunity to foster regional synergy and multidisciplinary research to promote harmonization of global strategies to treat and prevent dementia in underserved populations. ReDLat will develop an innovative, harmonized, and cross-regional approach on two of their most prevalent neurodegenerative disorders: Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
ReDLat will identify the genetic and socioeconomic/social determinants of health (SES/SDH) risks of AD and FTD in LACs vs. US. By analyzing 4,000 participants from Argentina, Chile, Colombia, Brazil, Mexico, Peru and US, outcomes will include (1) Genetic contributions to AD-FTD, (2) SES/SDH contributions on clinical-cognitive-neuroimaging signatures; (3) Machine-learning differentiation of genetic and SES/SDH risks.